The primary research focus of the Kampmann lab is the elucidation of the molecular and cellular mechanisms underlying neurodegenerative diseases, in particular tauopathies, with the ultimate goal to uncover new therapeutic approaches. To this aim, we have pioneered CRISPR-based screening approaches in human iPSC-derived neurons and glia, which have enabled us to uncover cellular pathways relevant to disease in an unbiased manner. The proposed project is therefore central to our research interests and builds on preliminary results we have obtained collaboratively with the co-investigators. The proposed research is distinct from previously funded research in the Kampmann lab, since it investigates for the first time mechanisms controlling disease-specific tau strains, in a novel collaboration with the co-investigators.